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acetaminophen 250 mg aspirin 250 mg caffeine 65 mg - l374 oval white

acetaminophen 250 mg / aspirin 250 mg / caffeine 65 mg oral tablet - l374 oval white

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Active Ingredients (in Each Caplet)

Acetaminophen 250 mg

Aspirin 250 mg (NSAID*)

Caffeine 65 mg

*nonsteroidal anti-inflammatory drug


Pain reliever

Pain reliever aid


  • •treats migraine


Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
  • •skin reddening
  • •bulers
  • •rash

If a skin reaction occurs, stop use and seek medical help right away.

Allergy alert: Aspirin may cause a severe allergic reaction which may include:
  • •hives
  • •facial swelling
  • •asthma (wheezing)
  • •shock

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
  • •more than 2 caplets in 24 hours, which is the maximum daily amount
  • •with other drugs containing acetaminophen
  • •3 or more alcoholic drinks every day while using this product

Stomach bleeding warning:

This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
  • •are age 60 or older
  • •have had stomach ulcers or bleeding problems
  • •take a blood thinning (anticoagulant) or steroid drug
  • •take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  • •have 3 or more alcoholic drinks every day while using this product
  • •take more or for a longer time than directed

Medication overuse headache warning: Headaches may worsen if this product is used for 10 or more days per month.

Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee. Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

Do not use

  • •if you have ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
  • •with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist

Ask a doctor before use if

  • •you have never had migraines diagnosed by a health professional
  • •you have a headache that is different from your usual migraines
  • •you have the worst headache of your life
  • •you have fever and stiff neck
  • •you have headaches beginning after or caused by head injury, exertion, coughing or bending
  • •you experienced your first headache after the age of 50
  • •you have daily headaches
  • •you have a migraine so severe as to require bed rest
  • •you have liver disease
  • •stomach bleeding warning applies to you
  • •you have a history of stomach problems, such as heartburn
  • •you have high blood pressure, heart disease, liver cirrhosis, or kidney disease
  • •you are taking a diuretic
  • •you have asthma
  • •you have problems or serious side effects from taking pain relievers or fever reducers
  • •you have vomiting with your migraine headache

Ask a doctor or pharmacist before use if you are

  • •taking a prescription drug for:
  • •diabetes
  • •gout
  • •arthritis
  • •under a doctor’s care for any serious condition
  • •taking any other drug
  • •taking any other product that contains aspirin, acetaminophen, or any other pain reliever/fever reducer

Stop use and ask a doctor if

  • •an allergic reaction occurs. Seek medical help right away.
  • •you experience any of the following signs of stomach bleeding:
  • •feel faint
  • •vomit blood
  • •have bloody or black stools
  • •have stomach pain that does not get better
  • •your migraine is not relieved or worsens after first dose
  • •new or unexpected symptoms occur
  • •ringing in the ears or loss of hearing occurs

If pregnant or breast-feeding,

ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.


  • do not use more than directed
  • •adults: take 2 caplets with a glass of water
  • •if symptoms persist or worsen, ask your doctor
  • •do not take more than 2 caplets in 24 hours, unless directed by a doctor
  • •under 18 years of age: ask a doctor

Other Information

  • •store at 20°-25°C (68°-77°F)
  • •close cap tightly after use
  • •read all product information before using. Keep this box for important information.

Inactive Ingredients

carnauba wax, crospovidone, FD&C blue #1 aluminum lake, hypromellose, microcrystalline cellulose, povidone, pregelatinized starch, propylene glycol, saccharin sodium, stearic acid, titanium dioxide

Questions Or Comments?


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migraine relief

Acetaminophen, Aspirin (NSAID) and Caffeine Tablets



Actual Size


**Capsule-Shaped Tablets


"This tool does not provide medical advice, and is for informational and educational purposes only, and is not a substitute for professional medical advice, treatment or diagnosis. Call your doctor to receive medical advice. If you think you may have a medical emergency, please dial 911."

"Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service."

"This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product."

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