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Propofol 1% Dailymed

Generic: propofol 1% is used for the treatment of Delirium Lactation Pain Pregnancy Pregnancy, Abdominal Psychomotor Agitation Respiratory Insufficiency Status Epilepticus Unconsciousness Postoperative Nausea and Vomiting

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Description Section

Propofol injectable emulsion, USP is a sterile, nonpyrogenic white or almost white, homogeneous emulsion, containing 10 mg/mL of propofol, USP suitable for intravenous administration. Propofol, USP is chemically described as 2,6-diisopropylphenol and has a molecular weight of 178.27. The structural formula is:

Propofol, USP is slightly soluble in water and, thus, is formulated in a white, oil-in-water emulsion. The pKa is 11. The octanol/water partition coefficient for propofol, USP is 6761:1 at a pH of 4.5 to 7.4. In addition to the active component, propofol, USP the formulation also contains soybean oil (100 mg/mL), glycerol (22.5 mg/mL), egg phospholipids (12 mg/mL); and benzyl alcohol (0.15%); with sodium hydroxide to adjust pH. Propofol injectable emulsion, USP is isotonic and has a pH of 5.5 to 7.4.

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