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Metformin Hydrochloride Metformin hydrochloride 1000 MG Oral Tablet

INDICATIONS AND USE Metformin HCL Tablets, USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 2 diabetes mellitus.

AvKARE, Inc.


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3 years ago OVAL WHITE IP220 10 00 Metformin Hydrochloride   Metformin hydrochloride 1000 MG Oral Tablet

OVAL WHITE IP220 10 00

3 years ago OVAL WHITE IP220 10 00 Metformin Hydrochloride   Metformin hydrochloride 1000 MG Oral Tablet

IP220 10 00 OVAL WHITE

HOW SUPPLIED Metformin HCL Tablets, USP 500 mg are blackberry flavored, white to off-white, round, biconvex, film-coated tablets debossed "IP 218" on obverse and "500" on the reverse. They are available as follows: Bottles of 60: NDC 42291-605-60 Bottles of 90: NDC 42291-605-90 Bottles of 120: NDC 42291-605-12 Bottles of 180: NDC 42291-605-18 Bottles of 270: NDC 42291-605-27 Bottles of 360: NDC 42291-605-36 Bottles of 450: NDC 42291-605-45 Bottles of 1000: NDC 42291-605-10 Metformin HCL Tablets, USP 850 mg are blackberry flavored, white to off-white, round, biconvex, film-coated tablets debossed "IP 219" on obverse and "850" on the reverse. They are available as follows: Bottles of 90: NDC 42291-606-90 Bottles of 180: NDC 42291-606-18 Bottles of 270: NDC 42291-606-27 Bottles of 1000: NDC 42291-606-10 Metformin HCL Tablets, USP 1000 mg are blackberry flavored, white to off-white, oval, biconvex, bisected, film-coated tablets debossed "IP 220" on obverse and "1000" on the reverse. They are available as follows: Bottles of 60: NDC 42291-607-60 Bottles of 90: NDC 42291-607-90 Bottles of 180: NDC 42291-607-18 Bottles of 1000: NDC 42291-607-10 Storage Store at 20° to 25° C (68° to 77° F); excursions permitted to 15° to 30° C (59° to 86° F). [See USP Controlled Room Temperature.] Dispense in light-resistant containers. Manufactured for: AvKARE, Inc. Pulaski, TN 38478 Mfg. Rev. 04/14 AV Rev. 08/14 (P) PATIENT INFORMATION Metformin Hydrochloride Tablets, USP Read this information carefully before you start taking this medicine and each time you refill your prescription. There may be new information. This information does not take the place of your doctor’s advice. Ask your doctor or pharmacist if you do not understand some of this information or if you want to know more about this medicine. What is Metformin HCL? Metformin HCL is used to treat type 2 diabetes. This is also known as noninsulin- dependent diabetes mellitus. People with type 2 diabetes are not able to make enough insulin or respond normally to the insulin their bodies make. When this happens, sugar (glucose) builds up in the blood. This can lead to serious medical problems including kidney damage, amputations, and blindness. Diabetes is also closely linked to heart disease. The main goal of treating diabetes is to lower your blood sugar to a normal level. High blood sugar can be lowered by diet and exercise, by a number of medicines taken by mouth, and by insulin shots. Before you take Metformin HCL, try to control your diabetes by exercise and weight loss. While you take your diabetes medicine, continue to exercise and follow the diet advised for your diabetes. No matter what your recommended diabetes management plan is, studies have shown that maintaining good blood sugar control can prevent or delay complications of diabetes, such as blindness. Metformin HCL helps control your blood sugar in a number of ways. These include helping your body respond better to the insulin it makes naturally, decreasing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. Metformin HCL does not cause your body to make more insulin. Because of this, when taken alone, they rarely cause hypoglycemia (low blood sugar), and usually do not cause weight gain. However, when they are taken with a sulfonylurea or with insulin, hypoglycemia is more likely to occur, as is weight gain. WARNING: A small number of people who have taken Metformin HCL have developed a serious condition called lactic acidosis. Lactic acidosis is caused by a buildup of lactic acid in the blood. This happens more often in people with kidney problems. Most people with kidney problems should not take Metformin HCL. (See “ What are the side effects of Metformin HCL? ”) Who should not take Metformin HCL? Some conditions increase your chance of getting lactic acidosis, or cause other problems if you take either of these medicines. Most of the conditions listed below can increase your chance of getting lactic acidosis. Do not take Metformin HCL if you: have kidney problems have liver problems have heart failure that is treated with medicines, such as Lanoxin ® (digoxin) or Lasix ® (furosemide) drink a lot of alcohol. This means you binge drink for short periods or drink all the time are seriously dehydrated (have lost a lot of water from your body) are going to have an x-ray procedure with injection of dyes (contrast agents) are going to have surgery develop a serious condition, such as heart attack, severe infection, or a stroke are 80 years or older and you have NOT had your kidney function tested Tell your doctor if you are pregnant or plan to become pregnant. Metformin HCL may not be right for you. Talk with your doctor about your choices. You should also discuss your choices with your doctor if you are nursing a child. Can Metformin HCL be used in children? Metformin HCL has been shown to effectively lower glucose levels in children (ages 10 to 16 years) with type 2 diabetes. Metformin HCL has not been studied in children younger than 10 years old. Metformin HCL has not been studied in combination with other oral glucose-control medicines or insulin in children. If you have any questions about the use of Metformin HCL in children, talk with your doctor or other healthcare provider. How should I take Metformin HCL? Your doctor will tell you how much medicine to take and when to take it. You will probably start out with a low dose of the medicine. Your doctor may slowly increase your dose until your blood sugar is better controlled. You should take Metformin HCL with meals. Your doctor may have you take other medicines along with Metformin HCL to control your blood sugar. These medicines may include insulin shots. Taking Metformin HCL with insulin may help you better control your blood sugar while reducing the insulin dose. Continue your exercise and diet program and test your blood sugar regularly while taking Metformin HCL. Your doctor will monitor your diabetes and may perform blood tests on you from time to time to make sure your kidneys and your liver are functioning normally. There is no evidence that Metformin HCL causes harm to the liver or kidneys. Tell your doctor if you: have an illness that causes severe vomiting, diarrhea or fever, or if you drink a much lower amount of liquid than normal. These conditions can lead to severe dehydration (loss of water in your body). You may need to stop taking Metformin HCL for a short time. plan to have surgery or an x-ray procedure with injection of dye (contrast agent). You may need to stop taking Metformin HCL for a short time. start to take other medicines or change how you take a medicine. Metformin HCL can affect how well other drugs work, and some drugs can affect how well Metformin HCL work. Some medicines may cause high blood sugar. What should I avoid while taking Metformin HCL? Do not drink a lot of alcoholic drinks while taking Metformin HCL. This means you should not binge drink for short periods, and you should not drink a lot of alcohol on a regular basis. Alcohol can increase the chance of getting lactic acidosis. What are the side effects of Metformin HCL? Lactic Acidosis. In rare cases, Metformin HCL can cause a serious side effect called lactic acidosis. This is caused by a buildup of lactic acid in your blood. This build-up can cause serious damage. Lactic acidosis caused by Metformin HCL is rare and has occurred mostly in people whose kidneys were not working normally. Lactic acidosis has been reported in about one in 33,000 patients taking Metformin HCL over the course of a year. Although rare, if lactic acidosis does occur, it can be fatal in up to half the people who develop it. It is also important for your liver to be working normally when you take Metformin HCL. Your liver helps remove lactic acid from your blood. Make sure you tell your doctor before you use Metformin HCL if you have kidney or liver problems. You should also stop using Metformin HCL and call your doctor right away if you have signs of lactic acidosis. Lactic acidosis is a medical emergency that must be treated in a hospital. Signs of lactic acidosis are: feeling very weak, tired, or uncomfortable unusual muscle pain trouble breathing unusual or unexpected stomach discomfort feeling cold feeling dizzy or lightheaded suddenly developing a slow or irregular heartbeat If your medical condition suddenly changes, stop taking Metformin HCL and call your doctor right away. This may be a sign of lactic acidosis or another serious side effect. Other Side Effects. Common side effects of Metformin HCL include diarrhea, nausea, and upset stomach. These side effects generally go away after you take the medicine for a while. Taking your medicine with meals can help reduce these side effects. Tell your doctor if the side effects bother you a lot, last for more than a few weeks, come back after they’ve gone away, or start later in therapy. You may need a lower dose or need to stop taking the medicine for a short period or for good. About 3 out of every 100 people who take Metformin HCL have an unpleasant metallic taste when they start taking the medicine. It lasts for a short time. Metformin HCL rarely causes hypoglycemia (low blood sugar) by themselves. However, hypoglycemia can happen if you do not eat enough, if you drink alcohol, or if you take other medicines to lower blood sugar. General advice about prescription medicines If you have questions or problems, talk with your doctor or other healthcare provider. You can ask your doctor or pharmacist for the information about Metformin HCL that is written for health care professionals. Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet. Do not use Metformin HCL for a condition for which it was not prescribed. Do not share your medicine with other people. Questions or comments? Call 1-855-361-3993 Monday through Friday 9AM to 5PM EST. Trademarks are the property of their respective owners.

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